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Ageing

Chromatin unbound

Sir2 proteins slow ageing in yeast by locking chromatin — the DNA and proteins in chromosomes — into a stable, silent state. Inactivating a Sir2 family protein in mice causes premature ageing and genome instability.

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Figure 1: Balancing act.

References

  1. Mostoslavsky, R. et al. Cell 124, 315–329 (2006).

    Article  CAS  Google Scholar 

  2. Henshaw, P. S., Riley, E. F. & Stapleton, G. E. Radiology 49, 349–364 (1947).

    Article  CAS  Google Scholar 

  3. Szilard, L. Proc. Natl Acad. Sci. USA 45, 30–45 (1959).

    Article  ADS  CAS  Google Scholar 

  4. Hasty, P., Campisi, J., Hoeijmakers, J., van Steeg, H. & Vijg, J. Science 299, 1355–1359 (2003).

    Article  CAS  Google Scholar 

  5. Vijg, J. & Suh, Y. Annu. Rev. Med. 56, 193–212 (2005).

    Article  CAS  Google Scholar 

  6. Motta, M. C. et al. Cell 116, 551–563 (2004).

    Article  CAS  Google Scholar 

  7. Cheng, H. L. et al. Proc. Natl Acad. Sci. USA 100, 10794–10799 (2003).

    Article  ADS  CAS  Google Scholar 

  8. Taub, D. D. & Longo, D. L. Immunol. Rev. 205, 72–93 (2005).

    Article  CAS  Google Scholar 

  9. Bartke, A. Endocrinology 146, 3718–3723 (2005).

    Article  CAS  Google Scholar 

  10. Wijnhoven, S. W. et al. DNA Repair (Amst.) 4, 1314–1324 (2005).

    Article  CAS  Google Scholar 

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Vijg, J., Suh, Y. Chromatin unbound. Nature 440, 874–875 (2006). https://doi.org/10.1038/440874a

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