Brief Communication | Published:

Allograft theory

Transmission of devil facial-tumour disease

Nature volume 439, page 549 (02 February 2006) | Download Citation

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Abstract

The Tasmanian devil, a large carnivorous Australian marsupial, is under threat from a widespread fatal disease in which a malignant oral–facial tumour obstructs the animal's ability to feed1. Here we show that the chromosomes in these tumours have undergone a complex rearrangement that is identical for every animal studied. In light of this remarkable finding and of the known fighting behaviour of the devils2, we propose that the disease is transmitted by allograft, whereby an infectious cell line is passed directly between the animals through bites they inflict on one another.

An uncanny similarity in the karyotype of these malignant tumours means that they could be infective.

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Author information

Affiliations

  1. Department of Primary Industries, Water and Environment. PO Box 46, Kings Meadows, Tasmania 7249, Australia

    • A.-M. Pearse
    •  & K. Swift

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to A.-M. Pearse.

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DOI

https://doi.org/10.1038/439549a

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