Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Metabolism

Bile acids heat things up

Nature volume 439, pages 402–403 (2006)Cite this article

Thyroid hormone causes fat loss, but harnessing this action to treat obesity is difficult because it is associated with harmful side effects. However, bile acids generate active thyroid hormone just where it is needed.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Bile acids in energy homeostasis.

References

  1. Hedley, A. A. et al. J. Am. Med. Assoc. 291, 2847–2850 (2004).

    Article  CAS  Google Scholar 

  2. Gaede, P. et al. N. Engl. J. Med. 348, 383–393 (2003).

    Article  Google Scholar 

  3. Watanabe, M. et al. Nature 439, 484–489 (2006).

    Article  ADS  CAS  Google Scholar 

  4. Spiegelman, B. M. & Flier, J. S. Cell 104, 531–544 (2001).

    Article  CAS  Google Scholar 

  5. Baxter, J. D. et al. Trends Endocrinol. Metab. 15, 154–157 (2004).

    Article  CAS  Google Scholar 

  6. Kawamata, Y. et al. J. Biol. Chem. 278, 9435–9440 (2003).

    Article  CAS  Google Scholar 

  7. Kalaany, N. Y. & Mangelsdorf, D. J. Annu. Rev. Physiol. doi:10.1146/annurev.physiol.68.033104.152158 (2005).

  8. Ikemoto, S. et al. Am. J. Physiol. 273, 37–45 (1997).

    Article  Google Scholar 

  9. Shoenfield, L. J. & Lachin, J. M. Ann. Intern. Med. 95, 257–282 (1981).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. the Diabetes Center and Department of Medicine, University of California School of Medicine, S1212, 513 Parnassus Avenue, San Francisco, 94143-0540, California, USA

    John D. Baxter & Paul Webb

  2. John D. Baxter & Paul Webb

Authors
  1. John D. Baxter
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Paul Webb
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Baxter, J., Webb, P. Bile acids heat things up. Nature 439, 402–403 (2006). https://doi.org/10.1038/439402a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/439402a

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing