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Developmental neuroscience

Two gradients are better than one

Wiring up retinal neurons to the correct brain region during development is a feat of precision growth. A novel directional cue repels retinal neuron fibres, acting as a counterbalance to a known attractive signal.

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Figure 1: Setting up the retinotopic map.


  1. McLaughlin, T. & O'Leary, D. D. Annu. Rev. Neurosci. 28, 327–355 (2005).

    Article  CAS  Google Scholar 

  2. Schmitt, A. M. et al. Nature 439, 31–37 (2006).

    Article  ADS  CAS  Google Scholar 

  3. Sperry, R. W. Proc. Natl Acad. Sci. USA 50, 703–710 (1963).

    Article  ADS  CAS  Google Scholar 

  4. Drescher, U. et al. Cell 82, 369–370 (1995).

    Article  Google Scholar 

  5. Cheng, H. -J., Nakamoto, M., Bergemann, A. D. & Flanagan, J. G. Cell 82, 371–381 (1995).

    Article  CAS  Google Scholar 

  6. Hindges, R., McLaughlin, T., Genoud, N., Henkemeyer, M. & O'Leary, D. D. Neuron 35, 475–487 (2002).

    Article  CAS  Google Scholar 

  7. Mann, F., Ray, S., Harris, W. & Holt, C. Neuron 35, 461–473 (2002).

    Article  CAS  Google Scholar 

  8. Logan, C. Y. & Nusse, R. Annu. Rev. Cell Dev. Biol. 20, 781–810 (2004).

    Article  CAS  Google Scholar 

  9. Yoshikawa, S., McKinnon, R. D., Kokel, M. & Thomas, J. B. Nature 422, 583–588 (2003).

    Article  ADS  CAS  Google Scholar 

  10. Lyuksyutova, A. I. et al. Science 302, 1984–1988 (2003).

    Article  ADS  CAS  Google Scholar 

  11. Liu, Y. et al. Nature Neurosci. 8, 1151–1159 (2005).

    Article  CAS  Google Scholar 

  12. McLaughlin, T., Hindges, R., Yates, P. A. & O'Leary, D. D. Development 130, 2407–2418 (2003).

    Article  CAS  Google Scholar 

  13. McLaughlin, T., Torborg, C. L., Feller, M. B. & O'Leary, D. D. Neuron 40, 1147–1160 (2003).

    Article  CAS  Google Scholar 

  14. Tessier-Lavigne, M. Cell 82, 345–348 (1995).

    Article  CAS  Google Scholar 

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Luo, L. Two gradients are better than one. Nature 439, 23–24 (2006).

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