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A painful factor

Peripheral nerve injury activates cells in the spinal cord called microglia. But how do such cells cause the ensuing chronic pain? It seems that they release a small protein that disrupts normal inhibition of pain signalling.

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Figure 1: A pathway of pain.


  1. Scholz, J. & Woolf, C. J. Nature Neurosci. 5, 1062–1067 (2002).

    Article  CAS  Google Scholar 

  2. Tsuda, M. et al. Nature 424, 778–783 (2003).

    Article  ADS  CAS  Google Scholar 

  3. Coull, J. A. et al. Nature 438, 1017–1021 (2005).

    Article  ADS  CAS  Google Scholar 

  4. Coull, J. A. et al. Nature 424, 938–942 (2003).

    Article  ADS  CAS  Google Scholar 

  5. Mantyh, P. W. & Hunt, S. P. Trends Neurosci. 27, 582–584 (2004).

    Article  CAS  Google Scholar 

  6. Nakajima, K. et al. J. Neurochem. 80, 697–705 (2002).

    Article  CAS  Google Scholar 

  7. Thompson, S. W. et al. Proc. Natl Acad. Sci. USA 96, 7714–7718 (1999).

    Article  ADS  CAS  Google Scholar 

  8. Rivera, C. et al. J. Cell Biol. 159, 747–752 (2002).

    Article  CAS  Google Scholar 

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Torsney, C., MacDermott, A. A painful factor. Nature 438, 923–924 (2005).

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