Brief Communication | Published:

Avian flu

Isolation of drug-resistant H5N1 virus

  • A Corrigendum to this article was published on 07 December 2005


The persistence of H5N1 avian influenza viruses in many Asian countries and their ability to cause fatal infections in humans have raised serious concerns about a global flu pandemic1. Here we report the isolation of an H5N1 virus from a Vietnamese girl that is resistant to the drug oseltamivir2, which is an inhibitor of the viral enzyme neuraminidase and is currently used for protection against and treatment of influenza. Further investigation is necessary to determine the prevalence of oseltamivir-resistant H5N1 viruses among patients treated with this drug.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Ethics declarations

Competing interests

The authors declare no competing financial interests.


  1. 1

    Enserink, M. Science 309, 370–371 (2005).

  2. 2

    Treanor, J. J. et al. J. Am. Med. Assoc. 283, 1016–1024 (2000).

  3. 3

    Gubareva, L. V., Kaiser, L. & Hayden, F. G. Lancet 355, 827–835 (2000).

  4. 4

    Gubareva, L. V., Kaiser, L., Matrosovich, M. N., Soo-Hoo, Y. & Hayden, F. G. J. Infect. Dis. 183, 523–531 (2001).

  5. 5

    Zambon, M. & Hayden, F. G. Antiviral Res. 47, 1–17 (2000).

  6. 6

    Potier, M., Mameli, L., Belisle, M., Dallaire, L. & Melancon, S. B. Anal. Biochem. 94, 287–296 (1979).

  7. 7

    Hurt, A. C., Barr, I. G., Gunter, H. & Hampson, A. W. Antiviral Res. 62, 37–45 (2004).

  8. 8

    Toms, G. L. R., Bird, R. A., Kingsman, S. M., Sweet, C. & Smith, H. Br. J. Exp. Pathol. 57, 37–48 (1977).

  9. 9

    Varghese, J. N., Laver, W. G. & Colman, P. M. Nature 303, 35–50 (1983).

  10. 10

    Varghese, J. N., McKimm-Breschkin, J. L., Caldwell, J. B., Kortt, A. A. & Colman, P. M. Proteins 11, 49–56 (1992).

  11. 11

    Shinya, K. et al. J. Virol. 79, 9926–9932 (2005).

Download references

Author information

Competing interests

The authors declare no competing financial interests.

Correspondence to Yoshihiro Kawaoka.

Supplementary information

Supplementary Information

Supplementary Methods, Supplemental references, Supplementary Table 1, Supplementary figure 1. (DOC 146 kb)

Rights and permissions

Reprints and Permissions

About this article

Further reading

Figure 1: Drug and binding sensitivity of H5N1 viral clones isolated from a human patient.


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.