Cellular lineages are defined by master regulatory proteins that dictate their fate and ensure their survival. The dependence on such factors of tumours that are resistant to treatment may prove to be their Achilles' heel.
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References
Garraway, L. A. et al. Nature 436, 117–122 (2005).
Loercher, A. E., Tank, E. M., Delston, R. B. & Harbour, J. W. J. Cell Biol. 168, 35–40 (2005).
Carreira, S. et al. Nature 433, 764–769 (2005).
Davies, H. et al. Nature 417, 949–954 (2002).
Pollock, P. M. et al. Nature Genet. 33, 19–20 (2003).
McGill, G. G. et al. Cell 109, 707–718 (2002).
Nishimura, E. K. et al. Nature 416, 854–860 (2002).
Nishimura, E. K., Granter, S. R. & Fisher, D. E. Science 307, 720–724 (2005).
Dean, M., Fojo, T. & Bates, S. Nature Rev. Cancer 5, 275–284 (2005).
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Merlino, G. The weakest link?. Nature 436, 33–35 (2005). https://doi.org/10.1038/436033a
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DOI: https://doi.org/10.1038/436033a