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A higher power for insulin

Glucose output from the liver is tightly regulated by insulin. But insulin holds sway over more than the liver — an unappreciated circuit in glucose control involves the opening of ion channels in the brain.

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Figure 1: Control of liver glucose production after a meal.


  1. Pocai, A. et al. Nature 434, 1026–1031 (2005).

    Article  ADS  CAS  Google Scholar 

  2. Schwartz, M. W. & Porte, D. Jr Science 307, 375–379 (2005).

    Article  ADS  CAS  Google Scholar 

  3. Obici, S., Zhang, B. B., Karkanias, G. & Rossetti, L. Nature Med. 8, 1376–1382 (2002).

    Article  CAS  Google Scholar 

  4. Spanswick, D., Smith, M. A., Mirshamsi, S., Routh, V. H. & Ashford, M. L. Nature Neurosci. 3, 757–758 (2000).

    Article  CAS  Google Scholar 

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Gribble, F. A higher power for insulin. Nature 434, 965–966 (2005).

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