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Jekyll or hide?

Many bacteria can adopt different lifestyles: in a free-living state, they are virulent and cause disease; in a surface-attached community, they are less virulent but may go unnoticed. How is this ‘decision’ made?

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Figure 1: Persistence versus infection.


  1. Goodman, A. L. et al. Dev. Cell 7, 745–754 (2004).

    Article  CAS  Google Scholar 

  2. Post, J. C., Stoodley, P. & Hall-Stoodley, L. Curr. Opin. Otolaryngol. Head Neck Surg. 12, 3185–3190 (2004).

    Article  Google Scholar 

  3. Friedman, L. & Kolter, R. J. Bacteriol. 186, 4457–4465 (2004).

    Article  CAS  Google Scholar 

  4. Friedman, L. & Kolter, R. Mol. Microbiol. 51, 675–690 (2004).

    Article  CAS  Google Scholar 

  5. Jackson, K. D., Starkey, M., Kremer, S., Parsek, M. R. & Wozniak, D. J. J. Bacteriol. 186, 4466–4475 (2004).

    Article  CAS  Google Scholar 

  6. Matsukawa, M. & Greenberg, E. P. J. Bacteriol. 186, 4449–4456 (2004).

    Article  CAS  Google Scholar 

  7. Singh, P. K., Parsek, M. R., Greenberg, E. P. & Welsh, M. J. Nature 417, 552–555 (2002).

    Article  ADS  CAS  Google Scholar 

  8. O'Toole, G. A. & Kolter, R. Mol. Microbiol. 30, 295–304 (1998).

    Article  CAS  Google Scholar 

  9. Irie, Y., Mattoo, S. & Yuk, M. H. J. Bacteriol. 186, 5692–5698 (2004).

    Article  CAS  Google Scholar 

  10. Kuchma, S. L., Connolly, J. P. & O'Toole, G. A. J. Bacteriol. (in the press).

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O'Toole, G. Jekyll or hide?. Nature 432, 680–681 (2004).

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