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Cell biology

Clathrin's Achilles' ankle

The protein clathrin forms lattice-like coats on transport vesicles that bud from cell membranes. High-resolution models of the lattice reveal interactions involved in its disassembly once the vesicles have formed.

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Figure 1: Views of the clathrin ‘triskelion’.

References

  1. Fotin, A. et al. Nature 432, 573–579 (2004).

    ADS  CAS  Article  Google Scholar 

  2. Fotin, A. et al. Nature 432, 649–653 (2004).

    ADS  CAS  Article  Google Scholar 

  3. Brodsky, F. M., Chen, C. Y., Knuehl, C., Towler, M. C. & Wakeham, D. E. Annu. Rev. Cell. Dev. Biol. 17, 517–568 (2001).

    CAS  Article  Google Scholar 

  4. Smith, C. J., Grigorieff, N. & Pearse, B. M. F. EMBO J. 17, 4943–4953 (1998).

    CAS  Article  Google Scholar 

  5. Ybe, J. A. et al. Nature 399, 371–375 (1999).

    ADS  CAS  Article  Google Scholar 

  6. ter Haar, E., Musacchio, A., Harrison, S. C. & Kirchhausen, T. Cell 95, 563–573 (1998).

    CAS  Article  Google Scholar 

  7. Chen, C. Y. et al. EMBO J. 21, 6072–6082 (2002).

    CAS  Article  Google Scholar 

  8. Näthke, I. et al. Cell 68, 899–910 (1992).

    Article  Google Scholar 

  9. Liu, S. -H., Wong, M. L., Craik, C. S. & Brodsky, F. M. Cell 83, 257–267 (1995).

    CAS  Article  Google Scholar 

  10. Ungewickell, E. et al. Nature 378, 632–635 (1995).

    ADS  CAS  Article  Google Scholar 

  11. Lemmon, S. K. Curr. Biol. 11, R49–R52 (2001).

    CAS  Article  Google Scholar 

  12. Young, J. C., Barral, J. M. & Hartl, F. U. Trends Biochem. Sci. 28, 541–547 (2003).

    CAS  Article  Google Scholar 

  13. Smith, C. J. et al. J. Mol. Biol. 336, 461–471 (2004).

    CAS  Article  Google Scholar 

  14. Gruschus, J. M. et al. Biochemistry 43, 3111–3119 (2004).

    CAS  Article  Google Scholar 

  15. DeLuca-Flaherty, C., McKay, D. B., Parham, P. & Hill, B. L. Cell 62, 875–887 (1990).

    CAS  Article  Google Scholar 

  16. Schmid, S. L., Braell, W. A., Schlossman, D. M. & Rothman, J. E. Nature 311, 228–231 (1984).

    ADS  CAS  Article  Google Scholar 

  17. Wakeham, D. E., Chen, C. Y., Greene, B., Hwang, P. K. & Brodsky, F. M. EMBO J. 22, 4980–4990 (2003).

    CAS  Article  Google Scholar 

  18. Owen, D. J., Collins, B. M. & Evans, P. R. Annu. Rev. Cell. Dev. Biol. 20, 153–191 (2004).

    CAS  Article  Google Scholar 

Download references

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Brodsky, F. Clathrin's Achilles' ankle. Nature 432, 568–569 (2004). https://doi.org/10.1038/432568a

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