Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Medicinal chemistry

A worthy adversary for malaria

A remarkable set of antimalarial drug candidates has been developed by an international collaboration of scientists, using the age-old Chinese herbal medicine artemisinin as a template.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Get just this article for as long as you need it


Prices may be subject to local taxes which are calculated during checkout

Figure 1: Artemisinin and its analogues.


  1. Winstanley, P. A., Ward, S. A. & Snow, R. W. Microbes Infect. 4, 157–164 (2002).

    Article  CAS  Google Scholar 

  2. Vennerstrom, J. L. et al. Nature 430, 900–904 (2004).

    Article  ADS  CAS  Google Scholar 

  3. Klayman, D. L. Science 228, 1049–1055 (1985).

    Article  ADS  CAS  Google Scholar 

  4. Borstnik, K., Paik, I. H., Shapiro, T. A. & Posner, G. H. Int. J. Parasitol. 32, 1661–1667 (2002).

    Article  CAS  Google Scholar 

  5. O'Neill, P. M. & Posner, G. H. J. Medicin. Chem. 47, 2945–2964 (2004).

    Article  CAS  Google Scholar 

  6. Vroman, J. A., Alvim-Gaston, M. & Avery, M. A. Curr. Pharm. Design 5, 101–138 (1999).

    CAS  Google Scholar 

  7. Haynes, R. K. Curr. Opin. Infect. Dis. 14, 719–726 (2001).

    Article  CAS  Google Scholar 

  8. Posner, G. H. & Oh, C. H. J. Am. Chem. Soc. 114, 8328–8329 (1992).

    Article  CAS  Google Scholar 

  9. Wu, Y. K. Acc. Chem. Res. 35, 255–259 (2002).

    Article  CAS  Google Scholar 

  10. Eckstein-Ludwig, U. et al. Nature 424, 957–961 (2003).

    Article  ADS  CAS  Google Scholar 

  11. Vennerstrom, J. L., Dong, Y., Chollet, J. & Matile, H. US Patent 6,486,199 (2002).


Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

O'Neill, P. A worthy adversary for malaria. Nature 430, 838–839 (2004).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing