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Molecular biology

Cohesins slip sliding away

Nature volume 430, pages 520–521 (2004)Cite this article

Cohesin complexes have a central role in cell division, mediating the association between sister chromosomes. It now seems that cohesin binding is dynamic, adapting to changes in gene transcription.

Dividing cells face the monumental task of providing each progeny cell with a complete and accurate copy of the genome. During mitosis, the basic cell-division process, cells need to ensure that they send only one copy of every chromosome to each of the daughter cells. Cohesion between the two sister chromatids produced by chromosome duplication is essential to this process: following duplication, the sister chromatids are physically linked by an evolutionarily conserved, ring-shaped protein complex known as cohesin1.

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Figure 1: The ChIP–chip technique used by Lengronne et al.3 and Glynn et al.4.
Figure 2: Cohesins associate with zones of convergent transcription.

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Authors and Affiliations

  1. Laboratory of Molecular and Cellular Biology, National Institute of Diabetes & Digestive & Kidney Diseases, National Institutes of Health, Bethesda, 20892, Maryland, USA

    Karen E. Ross & Orna Cohen-Fix

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  1. Karen E. Ross
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  2. Orna Cohen-Fix
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Ross, K., Cohen-Fix, O. Cohesins slip sliding away. Nature 430, 520–521 (2004). https://doi.org/10.1038/430520b

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