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Signal transduction

Thumbs up for inactivation

Cellular signalling pathways depend on the proper activation and inactivation of mediators. New structural information reveals an unusual mechanism by which one such mediator, Rap1, is switched off.

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Figure 1: Switching G proteins on and off.
Figure 2: The active sites of some G-protein–GAP complexes.


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Rehmann, H., Bos, J. Thumbs up for inactivation. Nature 429, 138–139 (2004).

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