Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Signal transduction

Thumbs up for inactivation

Cellular signalling pathways depend on the proper activation and inactivation of mediators. New structural information reveals an unusual mechanism by which one such mediator, Rap1, is switched off.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: Switching G proteins on and off.
Figure 2: The active sites of some G-protein–GAP complexes.

References

  1. 1

    Daumke, O., Weyand, M., Chakrabarti, P. P., Vetter, I. R. & Wittinghofer, A. Nature 429, 197–200 (2004).

    ADS  CAS  Article  Google Scholar 

  2. 2

    Scheffzek, K. et al. Science 277, 333–338 (1997).

    CAS  Article  Google Scholar 

  3. 3

    Seewald, M. J., Korner, C., Wittinghofer, A. & Vetter, I. R. Nature 415, 662–666 (2002).

    ADS  CAS  Article  Google Scholar 

  4. 4

    Bos, J. L. Cancer Res. 49, 4682–4689 (1989).

    CAS  PubMed  PubMed Central  Google Scholar 

  5. 5

    Rittinger, K., Walker, P. A., Eccleston, J. F., Smerdon, S. J. & Gamblin, S. J. Nature 389, 758–762 (1997).

    ADS  CAS  Article  Google Scholar 

  6. 6

    Coleman, D. E. et al. Science 265, 1405–1412 (1994).

    ADS  CAS  Article  Google Scholar 

  7. 7

    Bos, J. L., de Rooij, J. & Reedquist, K. A. Nature Rev. Mol. Cell Biol. 2, 369–377 (2001).

    CAS  Article  Google Scholar 

  8. 8

    Zhang, Y. et al. Nature Cell Biol. 5, 578–581 (2003).

    CAS  Article  Google Scholar 

  9. 9

    Maheshwar, M. M. et al. Hum. Mol. Genet. 6, 1991–1996 (1997).

    CAS  Article  Google Scholar 

  10. 10

    Hart, P. A. & Marshall, C. J. Oncogene 5, 1099–1101 (1990).

    CAS  PubMed  Google Scholar 

Download references

Author information

Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Rehmann, H., Bos, J. Thumbs up for inactivation. Nature 429, 138–139 (2004). https://doi.org/10.1038/429138a

Download citation

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing