Prions are clumps of misshapen proteins that can be passed between cells without the need for genetic intermediaries. The parts of the proteins that account for such infectivity are now being dissected.
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Osherovich, L. Z., Cox, B. S., Tuite, M. F. & Weissman, J. S. PLoS Biol. 2, 0442–0451 (2004).
Chernoff, Y. O., Lindquist, S. L., Ono, B., Inge-Vechtomov, S. G. & Liebman, S. W. Science 268, 880–884 (1995).
Paushkin, S. V., Kushnirov, V. V., Smirnov, V. N. & Ter-Avanesyan, M. D. EMBO J. 15, 3127–3134 (1996).
Santoso, A., Chien, P., Osherovich, L. Z. & Weissman, J. S. Cell 100, 277–288 (2000).
Cummings, C. J. & Zoghbi, H. Y. Annu. Rev. Genomics Hum. Genet. 1, 281–328 (2000).
Crist, C. G., Nakayashiki, T., Kurahashi, H. & Nakamura, Y. Genes Cells 8, 603–618 (2003).
Weissmann, C. & Flechsig, E. Br. Med. Bull. 66, 43–60 (2003).
Parham, S. N., Resende, C. G. & Tuite, M. F. EMBO J. 20, 2111–2119 (2001).
Liu, J. J. & Lindquist, S. Nature 400, 573–576 (1999).
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Masison, D. Designer prions. Nature 429, 37–38 (2004). https://doi.org/10.1038/429037a