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Kip moving

The p27Kip1 protein inhibits cell proliferation, helping to prevent tumours developing. We now know that it also affects cell migration, by regulating Rho proteins. Does this function influence tumour progression?

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Figure 1: Dual function of a tumour suppressor.


  1. Besson, A., Gurian-West, M., Schmidt, A., Hall, A. & Roberts, J. M. Genes Dev. 18, 862–876 (2004).

    Article  CAS  Google Scholar 

  2. Philipp-Staheli, J., Payne, S. R. & Kemp, C. J. Exp. Cell Res. 264, 148–168 (2001).

    Article  CAS  Google Scholar 

  3. Philipp-Staheli, J. et al. Cancer Cell 1, 355–368 (2002).

    Article  Google Scholar 

  4. Slingerland, J. & Pagano, M. J. Cell. Physiol. 183, 10–17 (2000).

    Article  CAS  Google Scholar 

  5. McAllister, S. S., Becker-Hapak, M., Pintucci, G., Pagano, M. & Dowdy, S. F. Mol. Cell. Biol. 23, 216–228 (2003).

    Article  CAS  Google Scholar 

  6. Ridley, A. J. et al. Science 302, 1704–1709 (2003).

    Article  ADS  CAS  Google Scholar 

  7. Malliri, A. & Collard, J. G. Curr. Opin. Cell Biol. 15, 583–589 (2003).

    Article  CAS  Google Scholar 

  8. Friedl, P. & Wolf, K. Nature Rev. Cancer 3, 362–374 (2003).

    Article  CAS  Google Scholar 

  9. Sahai, E. & Marshall, C. J. Nature Cell Biol. 5, 711–719 (2003).

    Article  CAS  Google Scholar 

  10. Goukassian, D. et al. FASEB J. 15, 1877–1885 (2001).

    Article  CAS  Google Scholar 

  11. Kouvaraki, M. et al. Cancer 94, 2454–2465 (2002).

    Article  CAS  Google Scholar 

  12. Saez, A. et al. Br. J. Cancer 80, 1427–1434 (1999).

    Article  CAS  Google Scholar 

  13. Boettner, B. & van Aelst, L. Gene 286, 155–174 (2002).

    Article  CAS  Google Scholar 

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Collard, J. Kip moving. Nature 428, 705–708 (2004).

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