Newly made proteins are moved across cellular membranes through a protein channel. The crystal structure of this channel is now revealed and confirms expectations that it must change shape to allow proteins to pass.
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References
Blobel, G. & Dobberstein, B. J. Cell Biol. 67, 835–851 (1975).
Blobel, G. Proc. Natl Acad. Sci. USA 77, 1496–1500 (1980).
Schatz, P. J. & Beckwith, J. Annu. Rev. Genet. 24, 215–248 (1990).
de Keyzer, J., van der Does, C. & Driessen, A. J. Cell. Mol. Life Sci. 60, 2034–2052 (2003).
Rapoport, T. A., Jungnickel, B. & Kutay, U. Annu. Rev. Biochem. 65, 271–303 (1996).
Schiebel, E., Driessen, A. J., Hartl, F. U. & Wickner, W. Cell 64, 927–939 (1991).
Yahr, T. L. & Wickner, W. T. EMBO J. 19, 4393–4401 (2000).
Duong, F. EMBO J. 22, 4375–4384 (2003).
Do, H., Falcone, D., Lin, J., Andrews, D. W. & Johnson, A. E. Cell 85, 369–378 (1996).
Beckmann, R. et al. Cell 107, 361–372 (2001).
Hamman, B. D., Chen, J. C., Johnson, E. E. & Johnson, A. E. Cell 89, 535–544 (1997).
Hamman, B. D., Hendershot, L. M. & Johnson, A. E. Cell 92, 747–758 (1998).
van den Berg, B. et al. Nature 427, 36–44 (2004).
Zhu, X. et al. Science 272, 1606–1614 (1996).
Hunt, J. F. et al. Science 297, 2018–2026 (2002).
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Benach, J., Hunt, J. Shape-shifting protein channel. Nature 427, 24–25 (2004). https://doi.org/10.1038/427024a
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DOI: https://doi.org/10.1038/427024a
