Neurons in the retina turn on and off rapidly in response to light. With the discovery of mutations in human genes that mediate this quick turn-off, we have the first picture of its importance in visual perception.
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Blumer, K. The need for speed. Nature 427, 20–21 (2004). https://doi.org/10.1038/427020a
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DOI: https://doi.org/10.1038/427020a