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Prion diseases

A nucleic-acid accomplice?

Prion proteins that trigger a cascade of protein misfolding in the brain are suspected of being the sole transmissible cause of some brain-destroying diseases. But nucleic acids could be their partner in crime.

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References

  1. Griffith, J. S. Nature 215, 1043–1044 (1967).

    Article  CAS  PubMed  Google Scholar 

  2. Prusiner, S. B. Proc. Natl Acad. Sci. USA 95, 13363–13383 (1998).

    CAS  PubMed  PubMed Central  Google Scholar 

  3. Deleault, N. R., Lucassen, R. W. & Supattapone, S. Nature 425, 717–720 (2003).

    Article  CAS  PubMed  Google Scholar 

  4. Kocisko, D. A. et al. Nature 370, 471–474 (1994).

    Article  CAS  PubMed  Google Scholar 

  5. Caughey, B. et al. Adv. Prot. Chem. 57, 139–169 (2001).

    CAS  Google Scholar 

  6. Saborio, G. P., Permanne, B. & Soto, C. Nature 411, 810–813 (2001).

    Article  CAS  PubMed  Google Scholar 

  7. Nandi, P. K., Leclerc, E., Nicole, J. C. & Takahashi, M. J. Mol. Biol. 322, 153–161 (2002).

    Article  CAS  PubMed  Google Scholar 

  8. Cordeiro, Y. et al. J. Biol. Chem. 276, 49400–49409 (2001).

    Article  CAS  PubMed  Google Scholar 

  9. Gabus, C. et al. J. Biol. Chem. 276, 19301–19309 (2001).

    Article  CAS  PubMed  Google Scholar 

  10. Meyer, N. et al. J. Gen. Virol. 72, 37–49 (1991).

    Article  CAS  PubMed  Google Scholar 

  11. Wong, C. et al. EMBO J. 20, 377–386 (2001).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Ben-Zaken, O. et al. J. Biol. Chem. 278, 40041–40049 (2003).

    Article  CAS  PubMed  Google Scholar 

Download references

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Caughey, B., Kocisko, D. A nucleic-acid accomplice?. Nature 425, 673–674 (2003). https://doi.org/10.1038/425673a

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