Mutations in the presenilin protein are associated with Alzheimer's disease. It now seems that mutant presenilin could wreak havoc on neuronal functions by triggering the activation of certain genes.
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Fortini, M. Double trouble for neurons. Nature 425, 565–566 (2003). https://doi.org/10.1038/425565a
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DOI: https://doi.org/10.1038/425565a
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