The perfection of a fly's eye and the chaotic nature of tumours provide eloquent examples of the need to coordinate cell death and proliferation. The intricacies of the underlying mechanism are now being uncovered.
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Rothenberg, M., Jan, YN. The hippo hypothesis. Nature 425, 469–470 (2003). https://doi.org/10.1038/425469a
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DOI: https://doi.org/10.1038/425469a