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Physiology

Is brain sympathetic to bone?

The fat-derived hormone leptin is best known for its effects on weight. But it also influences bone density, and new work reveals a role for the sympathetic nervous system in mediating this effect.

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Figure 1: Molecular connections between fat, appetite, energy expenditure and bone mass.

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Correspondence to Jeffrey S. Flier.

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Flier, J. Is brain sympathetic to bone?. Nature 420, 619–621 (2002). https://doi.org/10.1038/420619a

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  • DOI: https://doi.org/10.1038/420619a

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