Sodium-ion channels usually open in response to a voltage change across the membrane in which they sit. But, surprisingly, a growth factor secreted by neurons also rapidly triggers the opening of a specific sodium channel.
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Barde, YA. Neurotrophin channels excitement. Nature 419, 683–684 (2002). https://doi.org/10.1038/419683a
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DOI: https://doi.org/10.1038/419683a