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Signal transduction

Positive feedback from coffee

Caffeine acts on our nerve cells to wake us up. It turns out that it does so through a molecular signalling pathway that involves a positive feedback loop, boosting caffeine's effects from inside the cell.

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Figure 1: How coffee wakes up your nerve cells, based on work by Lindskog et al.1.


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Correspondence to Jean-Marie Vaugeois.

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Vaugeois, JM. Positive feedback from coffee. Nature 418, 734–736 (2002).

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