Abnormal enlargement of the heart muscle can be life-threatening. Unexpected insight into the underlying molecular mechanisms has come from investigating a gene that regulates cardiac calcium levels.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Xin, H.-B et al. Nature 416, 334–337 (2002).
Shou, W. et al. Nature 391, 489–492 (1998).
Molkentin, J. D. et al. Cell 93, 215–228 (1998).
Graef, I. A., Chen, F., Chen, L., Kuo, A. & Crabtree, G. R. Cell 105, 863–875 (2001).
Stevenson, A. S., Gomez, M. F., Hill-Eubanks, D. C. & Nelson, M. T. J. Biol. Chem. 276, 15018–15024 (2001).
Marks, A. R. Physiol. Rev. 76, 631–649 (1996).
Mendelsohn, M. E. & Karas, R. H. N. Engl. J. Med. 340, 1801–1811 (1999).
Wellman, G. C., Bonev, A. D., Nelson, M. T. & Brayden, J. E. Circ. Res. 79, 1024–1030 (1996).
Geary, G. G. et al. J. Appl. Physiol. 91, 2391–2399 (2001).
Zhu, Y. et al. Science 295, 505–508 (2002).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Nelson, M., Herrera, G. Protecting the heart. Nature 416, 273–274 (2002). https://doi.org/10.1038/416273a
Issue Date:
DOI: https://doi.org/10.1038/416273a
This article is cited by
-
Activation of AMPK inhibits cardiomyocyte hypertrophy by modulating of the FOXO1/MuRF1 signaling pathway in vitro
Acta Pharmacologica Sinica (2010)
-
Inhibitory effect of trilinolein on endothelin-1-induced c-fos gene expression in cultured neonatal rat cardiomyocytes
Naunyn-Schmiedeberg's Archives of Pharmacology (2005)