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FAT and bipolar affective disorder

Molecular Psychiatry volume 12, pages 899–900 (2007)Cite this article

An article recently published in Molecular Psychiatry1 reported that the cadherin gene (FAT) was associated with increased occurrence of bipolar affective disorder (BPAD) in four independent cohorts. The present investigation attempted to replicate these findings in a different cohort but found no significant association.

The heritable component of BPAD is unequivocal yet the identity of any risk allele remains to be consistently replicated. One proposed susceptibility locus occurs on chromosome 4q35.2, 3, 4 Blair et al.1 undertook positional cloning, association tests and gene expression assays and found support for a role of the FAT gene, that resides within that chromosomal region, in relation to BPAD.

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Authors and Affiliations

  1. Department of Psychological Medicine, University of Otago, Christchurch, New Zealand

    K J Light, A L Miller, C J Doughty, P R Joyce, R J Olds & M A Kennedy

Authors
  1. K J Light
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  2. A L Miller
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  3. C J Doughty
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  4. P R Joyce
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  5. R J Olds
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  6. M A Kennedy
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Correspondence to K J Light.

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Light, K., Miller, A., Doughty, C. et al. FAT and bipolar affective disorder. Mol Psychiatry 12, 899–900 (2007). https://doi.org/10.1038/sj.mp.4002040

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