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Pooled genome-wide linkage data on 424 ADHD ASPs suggests genetic heterogeneity and a common risk locus at 5p13

Molecular Psychiatry volume 11, pages 5–8 (2006)Cite this article

Attention-deficit/hyperactivity disorder (ADHD (MIM 143465)) is a common neurobehavioral disorder characterized by childhood onset and impairment in multiple settings. ADHD affects ∼5% of children and adolescents and ∼3% of adults, with a 3–4-fold prevalence in males1 and similar prevalence rates observed across diverse populations. Heritability estimates of 60–90% and reported sibling relative risks (λs) of ∼4–8 support a strong genetic etiology.2, 3

Currently, three genome-wide linkage studies from distinct ADHD populations have been published, one using extended kindreds from a population isolate,4 and two others using affected sibling pair (ASP) sampling. The University of California at Los Angeles (UCLA) study5, 6 comprises 308 ASPs and parents recruited from multiple sources in the greater Los Angeles area.7 The Utrecht University study8 contains 164 ASPs and parents of Dutch, Caucasian ancestry, recruited from different outpatient clinics in The Netherlands. Both studies employed the DSM-IV criteria for diagnoses of ADHD. A third genome scan in extended kindreds from a population isolate has been published,4 and comparison to the results of the joint analysis is discussed further on.

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Acknowledgements

Drs Buitelaar, Monaco, Nelson, Sinke, and Smalley contributed equally to this work. We thank Allen Day for indispensable technical advice and the UCLA DNA Microarray Facility for use of their equipment. We thank the families for their participation and Drs McGough, McCracken, Minderaa and Gunnin for clinical expertise in diagnoses. The project was completed with the support of the NIMH (MH1458277: Smalley), Wellcome Trust (Monaco), and with support of the Genvlag Program of UMC Utrecht (to Sinke and Buitelaar). Dr Monaco is a Wellcome Trust Principal Research Fellow. Dr Fisher is a Royal Society Research Fellow.

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Authors and Affiliations

  1. Department of Human Genetics, UCLA, Los Angeles, CA, USA

    M N Ogdie, R M Cantor & S F Nelson

  2. Department of Medical Genetics, University Medical Center, Utrecht, The Netherlands

    S C Bakker, P Pearson & R J Sinke

  3. Wellcome Trust Centre for Human Genetics, Oxford University, Oxford, UK

    S E Fisher, C Francks & A Monaco

  4. Center for Neurobehavioral Genetics, UCLA, Los Angeles, CA, USA

    M H Yang, S K Loo, S F Nelson & S L Smalley

  5. Departments of Psychiatry and Biobehavioral Sciences, UCLA, Los Angeles, CA, USA

    S K Loo & S L Smalley

  6. Department of Child and Adolescent Psychiatry, University Medical Center, Utrecht, The Netherlands

    E van der Meulen

  7. Department of Psychiatry, University Medical Center, Nijmegen, The Netherlands

    J Buitelaar

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  1. M N Ogdie
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  2. S C Bakker
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  3. S E Fisher
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  4. C Francks
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  5. M H Yang
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  6. R M Cantor
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  7. S K Loo
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  8. E van der Meulen
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  9. P Pearson
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  10. J Buitelaar
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  11. A Monaco
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  12. S F Nelson
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  13. R J Sinke
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  14. S L Smalley
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Corresponding author

Correspondence to S L Smalley.

Additional information

Electronic References

Kruglyak Laboratory, http://www.fhcrc.org/labs/kruglyak/Downloads/ (for Genehunter)

Marshfield Research Foundation, http://research.marshfieldclinic.org/genetics/

Online Mendelian Inheritance in Man (OMIM), http://www.ncbi.nlm.nih.gov/Omim/

UCSC Genome Bioinformatics, http://genome.cse.ucsc.edu/

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Ogdie, M., Bakker, S., Fisher, S. et al. Pooled genome-wide linkage data on 424 ADHD ASPs suggests genetic heterogeneity and a common risk locus at 5p13. Mol Psychiatry 11, 5–8 (2006). https://doi.org/10.1038/sj.mp.4001760

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