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Psychosis and the genetic spectrum of bipolar disorder: evidence from linkage analysis

Molecular Psychiatry volume 11, pages 3–5 (2006)Cite this article

Linkage analysis of phenotypic subtypes can expedite detection of susceptibility genes and clarify the genetic relationship among disease subsets. There is growing interest in applying this strategy to bipolar disorder (BP), a complex psychiatric disease with a strong, yet poorly understood genetic component.

We have recently shown that linkage analysis of BP accompanied by psychosis (psychotic BP) suggests novel susceptibility loci for BP,1 and that BP in the absence of psychosis (nonpsychotic BP) shows evidence of linkage to different loci altogether.2 This suggests that phenotypic subtypes defined by the presence or absence of psychosis may identify different genetic variants of BP.

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Author notes

  1. J Liu

    Present address: Genome Institute of Singapore, Singapore

  2. T C Gilliam

    Present address: Department of Human Genetics, University of Chicago, Chicago, IL, USA

Authors and Affiliations

  1. Columbia Genome Center, Columbia University, New York, NY, USA

    R Cheng, N Park, S H Juo, J Liu, T C Gilliam & M Baron

  2. Department of Epidemiology, Columbia University, New York, NY, USA

    S H Juo

  3. Graduate Institute of Medical Genetics, Kaohsiung Medical University, Kaohsiung, Taiwan

    S H Juo

  4. Department of Psychiatry, Columbia University, New York, NY, USA

    J E Loth, J Endicott & M Baron

Authors
  1. R Cheng
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  2. N Park
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  3. S H Juo
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  4. J Liu
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  5. J E Loth
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  6. J Endicott
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  7. T C Gilliam
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  8. M Baron
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Cheng, R., Park, N., Juo, S. et al. Psychosis and the genetic spectrum of bipolar disorder: evidence from linkage analysis. Mol Psychiatry 11, 3–5 (2006). https://doi.org/10.1038/sj.mp.4001745

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