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  • Original Research Article
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Analysis of the disease risk locus DXS1047 polymorphism in Brazilian Alzheimer patients

Molecular Psychiatry volume 5, pages 563–566 (2000)Cite this article

Abstract

Alzheimer's disease (AD) is a disorder characterized by a progressive deterioration in memory and other cognitive functions. Four genes associated with early onset AD have been identified1, 2, 3, 4, 5 but familial AD is rare.6 The majority of late onset AD (LOAD) is caused by a complex inheritance with several genes interacting with environmental factors. The ε4 allele of the apolipoprotein E (APOE) gene has been reported worldwide as a risk factor associated with LOAD.7, 8, 9, 10 The short variant of a polymorphism in the transcriptional region of the serotonin transporter gene (5-HTTLPR) was analyzed in several psychiatric conditions11, 12, 13, 14, 15 and found to be more frequently associated with European16 and Brazilian LOAD patients.17, 18 Recently, allelic associations with LOAD were reported for five other loci,19, 20 the most significant for one X-linked 202-bp allele, at the DXS1047 locus. We have analyzed this locus in Brazilian LOAD patients and observed that the 202-bp allele was not significantly more frequent among patients. In contrast, two other alleles (200 bp and 208 bp) were less frequent among AD male patients than in controls, confirming the importance of replicating association studies in different populations.

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Acknowledgements

This work was supported with grants from FAPESP, CNPq and PRONEX. We are extremely grateful to Dr Maria Rita Passos-Bueno, Dr Mariz Vainzof, Dr José L Lima Filho, Marcos Morais, Luiz C Bezerra, to Constancia Urbani, Antonia Cerqueira, Marta Canovas, Andrea L Bernardino, Paula Lughetti, Eloísa S Moreira, Andréa Sertié and Fernanda Sarquis, for their invaluable help.

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Authors and Affiliations

  1. Department of Biology, Center of the Study of the Human Genome, Institute of Biosciences, University of São Paulo, Brazil

    A L Nishimura, J R M Oliveira, S R Matioli & M Zatz

  2. Laboratory of Immunopathology Keizo Asami, Federal University of Pernambuco, PE, Brazil

    J R M Oliveira

  3. Center of Cognitive Neurology and Behaviour of the University of Pernambuco, PE, Brazil

    P R Brito-Marques

  4. Department of Neurology, Faculty of Medicine, University of São Paulo, Brazil

    V S Bahia & R Nitrini

Authors
  1. A L Nishimura
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  2. J R M Oliveira
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  3. S R Matioli
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  4. P R Brito-Marques
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  5. V S Bahia
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  6. R Nitrini
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  7. M Zatz
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Correspondence to M Zatz.

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Nishimura, A., Oliveira, J., Matioli, S. et al. Analysis of the disease risk locus DXS1047 polymorphism in Brazilian Alzheimer patients. Mol Psychiatry 5, 563–566 (2000). https://doi.org/10.1038/sj.mp.4000767

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