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Identification of candidate genes for psychiatric disorders on 18p11

Molecular Psychiatry volume 5, pages 389–395 (2000)Cite this article

Abstract

Linkage studies have suggested a locus for bipolar disorder as well as schizophrenia in the pericentric region of chromosome 18. Several candidate genes have been identified in the region including ACTH, IMP, and G(olf), however no reports of mutations in families showing linkage to the 18p11 locus have been reported. Recently, mild linkage disequilibrium has been observed with a polymorphic marker that maps within the G(olf) gene and schizophrenia in families from Germany and Israel, suggesting that a gene mapping near G(olf) may be involved in psychiatric disorders. A BAC and cosmid contig around the G(olf) locus has been generated and BAC clones were used for cDNA selection experiments. Several novel genes have been identified which are expressed in the brain. These genes may be possible candidate genes for psychiatric illness.

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Acknowledgements

The chromosome 18-specific cosmid library, LL18NC02 used in this work was constructed at the Human Genome Center, Lawrence Livermore Laboratory (LLNL) under the auspices of the National Laboratory Gene Library Project sponsored by the US Department of Energy Contract No. W07405-ENG-48. This work was supported by a Distinguished Investigator Award to WHB by the National Alliance for Research on Schizophrenia and Depression (NARSAD).

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Pharmacology, Thomas Jefferson University, 233 S 10th Street, Suite 209, Philadelphia, 19107, PA, USA

    K Rojas, L Liang, E I Johnson & J Overhauser

  2. Department of Psychiatry, University of Pennsylvania, 415 Curie Blvd, Room 111, Philadelphia, 19104, PA, USA

    W H Berrettini

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  1. K Rojas
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  2. L Liang
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  3. E I Johnson
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  4. W H Berrettini
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  5. J Overhauser
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Correspondence to J Overhauser.

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Rojas, K., Liang, L., Johnson, E. et al. Identification of candidate genes for psychiatric disorders on 18p11. Mol Psychiatry 5, 389–395 (2000). https://doi.org/10.1038/sj.mp.4000737

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