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Efficacy of DA-8159, a new PDE5 inhibitor, for inducing penile erection in rabbits with acute spinal cord injury

International Journal of Impotence Research volume 15, pages 405–411 (2003)Cite this article

Abstract

DA-8159 is a pyrazolopyrimidinone derivative which exhibits potent and selective phosphodiesterase type 5 (PDE5) inhibition. The aim of this study was to investigate the effects of DA-8159 on inducing a penile erection in rabbits with an acute spinal cord injury (ASCI). DA-8159 was given either orally (1, 3, or 10 mg/kg) or intravenously (0.1 or 0.3 mg/kg) to conscious male albino rabbits with a surgical transection of the spinal cord at the L2–L4 lumbar vertebra or ischemic-reperfusion SCI rabbits. Erection was evaluated in a time-course manner by measuring the length of the uncovered penile mucosa. DA-8159 induced a dose-dependent erection in both transection and ischemic-reperfusion ASCI rabbits. The efficacy of DA-8159 was potentiated by an intravenous injection of sodium nitroprusside, a nitric oxide donor. Potentiation of the effect by nitric oxide donor implies that DA-8159 can enhance the erectile activity during sexual arousal. These results suggest that DA-8159 may be useful for treating erectile dysfunction in patients with an SCI.

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Authors and Affiliations

  1. Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University, Seoul, Korea

    BO Ahn, K-S Kang & Y-S Lee

  2. Research Laboratories of Dong-A Pharmaceutical Company, Yongin, Korea

    BO Ahn, KK Kang, GJ Ahn, JW Kwon & WB Kim

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  1. BO Ahn
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Correspondence to Y-S Lee.

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Ahn, B., Kang, K., Ahn, G. et al. Efficacy of DA-8159, a new PDE5 inhibitor, for inducing penile erection in rabbits with acute spinal cord injury. Int J Impot Res 15, 405–411 (2003). https://doi.org/10.1038/sj.ijir.3901055

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