Transcriptional repression by nuclear receptors has been correlated to binding of the putative co-repressor, N-CoR. A complex has been identified that contains N-CoR, the Mad presumptive co-repressor mSin3, and the histone deacetylase mRPD3, and which is required for both nuclear receptor- and Mad-dependent repression, but not for repression by transcription factors of the ets-domain family. These data predict that the ligand-induced switch of heterodimeric nuclear receptors from repressor to activator functions involves the exchange of complexes containing histone deacetylases with those that have histone acetylase activity.
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Heinzel, T., Lavinsky, R., Mullen, TM. et al. A complex containing N-CoR, mSln3 and histone deacetylase mediates transcriptional repression. Nature 387, 43–48 (1997). https://doi.org/10.1038/387043a0
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