Letter | Published:

Phase-contrast imaging using polychromatic hard X-rays

Abstract

IN conventional radiography, X-rays which pass through an object along different paths are differentially absorbed, and the intensity pattern of the emerging beam records the distribution of absorbing materials within the sample. An alternative approach is phase-contrast radiography, which instead records variations of the phase of the emerging radiation. Such an approach offers improved contrast sensitivity, especially when imaging weakly absorbing samples. Unfortunately, current phase-contrast imaging techniques1–11 generally require highly monochromatic plane-wave radiation and sophisticated X-ray optics, so their use is greatly restricted. Here we describe and demonstrate a simplified scheme for phase-contrast imaging based on an X-ray source having high spatial (but essentially no chromatic) coherence. The method is compatible with conventional polychromatic micro-focus X-ray tube sources, is well suited to large areas of irradiation, can operate with a lower absorbed dose than traditional X-ray imaging techniques, and should find broad application in clinical, biological and industrial settings.

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References

  1. 1

    Bonse, U. & Hart, M. Appl. Phys. Lett. 6, 155–156 (1965); Z Phys. 188, 154–164 (1965); Acta Crystallogr. A 24, 240–245 (1965).

  2. 2

    Momose, A., Takeda, T., Itai, Y. & Hirano, K. Nature Med. 2, 473–475 (1996).

  3. 3

    Forster, E., Goetz, K. & Zaumseil, P. Kristall und Technik 15, 937–945 (1980).

  4. 4

    Somenkov, V. A., Tkalich, A. K. & Shilstein, S. S. J. Tech. Phys. 61, 197–201 (1991).

  5. 5

    Belyaevskaya, E. A., Ingal, V. N. & Petrashen, P. V. Soviet Patent No. 4934958 (1991); US Patent No. 5319694 (1992).

  6. 6

    Ingal, V. N. & Beliaevskaya, E. A. J. Phys. D; Appl. Phys. 28, 2314–2317 (1995).

  7. 7

    Wilkins, S. W. Aust. Patent Applicn PM 1519/93 (1993); PCT Application PCT/AU94/00480 (1994).

  8. 8

    Davis, T. J., Gao, D., Gureyev, T. E., Stevenson, A. W. & Wilkins, S. W. Nature 373, 595–598 (1995); Phys. Rev. Lett. 74, 3173–3176 (1995).

  9. 9

    Snigirev, A., Snigireva, I., Suvorov, M., Kocsis, M. & Kohn, V. ESRF Newsl. 23–25 June (1995); Rev. Sci. Instrum. 66, 5486–5492 (1995).

  10. 10

    Cloetens, P., Barrett, R., Baruchel, J., Guigay, J.-P. & Schlenker, M. J. Phys. D; Appl. Phys. 29, 133–146 (1996).

  11. 11

    Nugent, K. A., Gureyev, T. E., Cookson, D. F., Paganin, D. & Bamea, Z. Phys. Rev. Lett. 77, 2961–2964 (1996).

  12. 12

    Gabor, D. Nature 161, 777–778 (1948).

  13. 13

    Wilkins, S. W. Aust. Patent Applicn PN 2112/95; PCT Patent Applicn PCT/AU96/00178 (1995).

  14. 14

    Cowley, J. M. Diffraction Physics 3rd edn (North Holland, Amsterdam, 1995).

  15. 15

    Guigay, J.-P. Optik 49, 121–125 (1977).

  16. 16

    Gureyev, T. E., Roberts, A. & Nugent, K. A. J. Opt. Soc. Am. A 12, 1932–1941 (1995); 12, 1942–1946 (1995).

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