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Regulation of rhythmic movements by purinergic neurotransmitters in frog embryos

Nature volume 383, pages 259263 (19 September 1996) | Download Citation

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Abstract

MANY rhythmic motor behaviours, including swimming1, walking2, scratching3, swallowing4, micturition5 and sexual climax6, are episodic: even in the absence of sensory inputs they exhibit a gradual run-down in frequency before spontaneously terminating. We have investigated whether the purinergic transmitters, ATP and adenosine, control run-down of swimming in the Xenopus embryo7. By using specific agonists and antagonists for the purinergic receptors, we have shown that ATP (or a related substance) is released during swimming and activates P2y receptors to reduce voltage-gated K+ currents and cause an increase in the excitability of the spinal motor circuits. Adenosine is also produced during motor activity, possibly through the actions of ectonucleotidases. The activation by adenosine of PI receptors reduces the voltage-gated Ca2+ currents, lowers excitability of the motor circuits, and so opposes the actions of ATP. A gradually changing balance between ATP and adenosine therefore seems to underlie the run-down of the motor pattern for swimming in Xenopus. We believe this to be the first time that ATP and adenosine have been found to be involved in motor pattern generation. The antagonistic interplay between these two transmitters may offer a general feedback mechanism that underlies run-down of all episodic motor patterns in vertebrates.

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Affiliations

  1. School of Biological and Medical Sciences, Bute Medical Building, University of St Andrews, St Andrews, KY16 9RU, UK

    • Nicholas Dale
  2. School of Biological Sciences, University of Bristol, Woodland Road, Bristol, BS8 1UG, UK

    • Deborah Gilday

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https://doi.org/10.1038/383259a0

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