Cell proliferation in many tissues is regulated by p27 protein, which binds and inhibits cyclin-dependent kinases. A crystal structure reveals the remarkable mechanisms by which p27 paralyses these enzymes, arresting the cell cycle.
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Morgan, D. Under arrest at atomic resolution. Nature 382, 295–296 (1996). https://doi.org/10.1038/382295a0
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DOI: https://doi.org/10.1038/382295a0