Integration of positional signals and regulation of wing formation and identity by Drosophila vestigial gene

Abstract

Appendage formation is organized by signals from discrete sources that presumably act upon downstream genes to control growth and patterning. The Drosophila vestigial gene is selectively required for wing-cell proliferation, and is sufficient to induce outgrowths of wing tissue from eyes, legs and antennae. Different signals activate separate enhancers to control vestigial expression: first, in the dorsal/ventral organizer through the Notch pathway, and subsequently, in the developing wing blade by decapentaplegic and a signal from the dorsal/ventral organizer. Signal integration must be a general feature of genes like vestigial, that regulate growth or patterning along more than one axis.

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References

  1. 1

    Tabin, C. Cell 80, 671–674 (1995).

  2. 2

    Riddle, R. D. et al. Cell 75, 1401–1416 (1993).

  3. 3

    Cohn, M. J. et al. Cell 80, 739–746 (1995).

  4. 4

    Parr, B. A. & McMahon, A. P. Nature 374, 350–353 (1995).

  5. 5

    Yang, Y. & Niswander, L. Cell 80, 939–947 (1995).

  6. 6

    Riddle, R. D. Cell 83, 631–640 (1995).

  7. 7

    Laufer, E. et al. Cell 79, 993–1003 (1994).

  8. 8

    Niswander, L. et al. Nature 371, 609–612 (1994).

  9. 9

    Crossley, P. H. et al. Cell 84, 127–136 (1996).

  10. 10

    Blair, S. S. BioEssays 17, 299–309 (1995).

  11. 11

    Lee, J. J. et al. Cell 71, 33–50 (1992).

  12. 12

    Tabata, T., Eaton, S. & Kornberg, T. B. Genes Dev. 6, 2635–2645 (1992).

  13. 13

    Basler, D. & Struhl, G. Nature 368, 208–214 (1994).

  14. 14

    Tabata, T. & Kornberg, T. G. Cell 76, 89–102 (1994).

  15. 15

    Sanicola, M. et al. Genetics 139, 745–756 (1995).

  16. 16

    Posakony, L., Raftery, L. & Gelbart, W. Mech. Dev. 33, 69–82 (1991).

  17. 17

    Capdevilla, J. & Guerrero, I. EMBO J. 6, 715–729 (1994).

  18. 18

    Ingham, P. & Feitz, M. J. Curr. Biol. 5, 432–440 (1995).

  19. 19

    Zecca, M., Basler, K. & Struhl, G. Development 121, 2265–2278 (1995).

  20. 20

    Diaz-Benjumea, F. & Cohen, S. M. Cell 75, 741–752 (1993).

  21. 21

    Cohen, B. et al. Genes Dev. 6, 715–729 (1992).

  22. 22

    Blair, S. et al. Development 120, 1805–1815 (1994).

  23. 23

    Irvine, K. & Wieschaus, E. Cell 79, 595–606 (1994).

  24. 24

    Spreicher, S. et al. Development 120, 535–544 (1994).

  25. 25

    Fleming, R. et al. Genes Dev. 4, 2188–2201 (1990).

  26. 26

    Kim, J., Irvine, K. D. & Carroll, S. B. Cell 82, 795–802 (1995).

  27. 27

    Couso, J. P., Knust, E. & Martinez Arias, A. Curr. Biol. 5, 1437–1448 (1995).

  28. 28

    Diaz-Benjumea, F. J. & Cohen, S. Development 121, 4215–4225 (1995).

  29. 29

    de Celis, J. F., Garcia-Bellido, A. & Bray, S. J. Development 122, 359–369 (1996).

  30. 30

    Simpson, P., Lawrence, P. A. & Maschat, F. Devl Biol. 84, 206–211 (1981).

  31. 31

    Brand, A. H. & Perrimon, N. Development 118, 401–415 (1993).

  32. 32

    di Pasquale, A. Ro. lst. lonb. Sci. Lett. III 85, 241–248 (1952).

  33. 33

    Ouweneel, W. J. Genetica 41, 1–20 (1970).

  34. 34

    Fortini, M. E. & Artavanis-Tsakonas, S. Cell 79, 273–282 (1994).

  35. 35

    Lecourtois, M. & Schweisguth, F. Genes Dev. 9, 2598–2608 (1995).

  36. 36

    Bailey, A. M. & Posakony, J. W. Genes Dev. 9, 2609–2622 (1995).

  37. 37

    Xu, T. & Rubin, G. M. Development 117, 1223–1237 (1993).

  38. 38

    Williams, J. et al. Nature 368, 299–305 (1994).

  39. 39

    Couso, J. P. & Martinez Arias, A. Cell 79, 259–272 (1994).

  40. 40

    Williams, J. A. et al. Development 117, 571–584 (1993).

  41. 41

    Couso, J. P., Bate, M. & Martinez-Arias, A. Science 259, 484–489 (1994).

  42. 42

    de Cellis, J. F. & García-Bellido, A. Mech. Dev. 46, 109–122 (1994).

  43. 43

    Doherty, D. et al. Genes Dev. 10, 421–434 (1996).

  44. 44

    Axelrod, J. D. et al. Science 271, 1826–1832 (1996).

  45. 45

    Nellen, D. et al. Cell 78, 225–237 (1994).

  46. 46

    Penton, A. et al. Cell 78, 239–250 (1994).

  47. 47

    Brummel, T. J. et al. Cell 78, 251–261 (1994).

  48. 48

    Nellen, D. et al. Cell 85, 357–368 (1996).

  49. 49

    Morimura, S. et al. Devl Biol. (in the press).

  50. 50

    Halder, G., Callaerts, P. & Gehring, W. J. Science 267, 1788–1792 (1995).

  51. 51

    Meinhardt, H. Semin. dev. Biol. 2, 129–138 (1991).

  52. 52

    French, V., Bryant, P. J. & Bryant, S. V. Science 193, 969–981 (1976).

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Kim, J., Sebring, A., Esch, J. et al. Integration of positional signals and regulation of wing formation and identity by Drosophila vestigial gene. Nature 382, 133–138 (1996). https://doi.org/10.1038/382133a0

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