The mammalian cell cycle is controlled by systems that monitor the cell's health and act through the tumour-suppressor p53 and its effector, p21. Therapeutic intervention can restore order to tumour cells lacking p53.
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References
Greenblatt, M. S., Bennett, W. P., Hollstein, M. & Harris, C. C. Cancer Res. 54, 4855–4878 (1994).
Waldman, T., Lengauer, C., Kinzler, K. W. & Vogelstein, B. Nature 381, 713–716 (1996).
Reed, S. I. Trends Cell Biol. 2, 77–81 (1992).
Hartwell, L. & Weinert, T. Science 246, 629–634 (1989).
Hartwell, L. H. & Kastan, M. B. Science 266, 1821–1828 (1994).
Lane, D. P. Nature 362, 786–787 (1993).
el-Deiry, W. S. et al. Cell 75, 817–825 (1993).
Xiong, Y. et al. Nature 366, 701–704 (1993).
Harper, J. W., Adami, G. R., Wei, N., Keyomarsi, K. & Elledge, S. J. Cell 75, 805–816 (1993).
Kastan, M. B. et al. Cell 71, 587–597 (1992).
DiLeonardo, A., Linke, S. P., Clarkin, K. & Wahl, G. M. Genes Dev. 8, 2540–2551 (1994).
Lane, D. P. Nature 358, 15–16 (1992).
Livingstone, L. R. et al. Cell 70, 923–935 (1992).
Yin, Y. et al. Cell 70, 937–948 (1992).
Wright, W. E. & Shay, J. W. Trends Cell Biol. 5, 293–297 (1995).
White, E. Genes Dev. 10, 1–15 (1996).
Debbas, M. & White, E. Genes Dev. 7, 546–554 (1993).
Graeber, T. G. et al. Nature 379, 88–91 (1996).
Deng, C. et al. Cell 82, 675–684 (1995).
Brugarolas, J. et al. Nature 377, 552–557 (1995).
Cross, S. M. et al. Science 267, 1353–1360 (1995).
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Jacks, T., Weinberg, R. Cell-cycle control and its watchman. Nature 381, 643–644 (1996). https://doi.org/10.1038/381643a0
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DOI: https://doi.org/10.1038/381643a0
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