Improved liposome stability and drug retention significantly increase the anticancer activity of encapsulated doxorubicin (Doxil), enhancing the effectiveness of chemotherapy and potentially reducing its toxicity.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Lasic, D. D. Liposomes: from Physics to Applications, (Elsevier, Amsterdam, 1993).
Lasic, D. D., Martin F. & Gabizon, A., Huang, K., Papahadjopoulos, D. Biochim. biophys. Acta 1070, 187–192 (1991).
Gregoriadis, G. & Senior, J. H. FEBS Lett. 119, 43–47 (1980).
Papahadjopoulos, D. et al. Proc. natn. Acad. Sci. U.S.A. 88, 11640–11644 (1991).
Klibanov, M., Maruyama, K., Torchilin, V. P. & Huang, L. FEBS Lett. 268, 235–237 (1990).
Blume, G. & Cevc, G. Biochim. biophys. Acta 1029, 91–97 (1990).
Senior, J. H., Delgado, C., Fisher, D., Tilcock, C. & Gregoriadis, G. Biochim. biophys. Acta 1062, 77–82 (1991).
Lasic, D. D. & Needham, D. Chem. Rev. 96, 1601–1624 (1995).
Needham, D. et al. J. Liposome Res. 2, 411–430 (1992).
Kuhl, T., Leckband, D., Lasic, D. D. & Israelachvili, J. N., Biophys. J. 66, 1479–1488 (1994).
deGennes P. G., Adv. Colloid Interface Sci. 27, 189–209 (1987).
Lasic, D. D. Angew. Chem. Int. Ed. Eng. 33, 1685–1698 (1994).
Lasic, D. D. & Martin, F. (Eds.) Stealth Liposomes, (CRC Press, Boca Raton, 1995).
Gabizon, A. et al. Cancer Res. 54, 987–992 (1994).
Gabizon, A. et al. Acta Oncologica 33, 779–786 (1994).
Lasic, D. D., Frederik. P. M., Stuart, M., Barenholz, Y. & Maclntosh T. J. FEBS Lett. 312, 255–258 (1992).
Haran, G., Cohen, R., Bar, L. K. & Barenholz, Y. Biochim. biophys. Acta 1151, 201–215 (1993).
Lasic, D. D., Ceh, B., Guo, L., Frederik, P. M., Barenholz, Y. Biochim. biophys. Acta 1239, 145–156 (1995).
Mayhew, E., Lasic, D. D., Babbar, S. & Matin, F. Int. J. Cancer 51, 302–309 (1992).
Vaage, J., Mayhew, E. Lasic, D. D. & Martin, F. Int. J. Cancer 51, 942–948 (1992).
Williams, S. S. et al. Cancer Res. 53, 3964–3967 (1993).
Uziely, B. et al. J. clin. Oncol. 13, 1777–1785 (1995).
Daemen, T., Hofstede, G., Ten Kate M. T., Bakker-Woudenberg, I. A. J. M. & Scherphof, G. L. Int.J. Cancer 61, 716–721 (1995).
Zheng, S. et al. J. Liposome Res. 3, 575–558, 1993.
Lasic, D. D. & Papahadjopoulos, D. Science 267, 1275–1276 (1995).
Bangham, A. D. BioEssays 17, 1081–1088 (1995).
Israelachvili, J. N. Surface and Interparticle Forces, (Academic Press, New York, 1985).
Ceh, B. & Lasic, D. D. Langmuir 11, 3356–3368 (1995).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Lasic, D. Doxorubicin in sterically stabilized liposomes. Nature 380, 561–562 (1996). https://doi.org/10.1038/380561a0
Issue Date:
DOI: https://doi.org/10.1038/380561a0
This article is cited by
-
Functional Amphiphilic Poly(2-oxazoline) Block Copolymers as Drug Carriers: the Relationship between Structure and Drug Loading Capacity
Chinese Journal of Polymer Science (2021)
-
Detailed biodistribution of liposomes prepared with polyborane instead of cholesterol for BNCT: effects of PEGylation
Colloid and Polymer Science (2017)
-
Investigation of the self-assembly of CS and PCL copolymers with different molecular weights in water solution by coarse-grained molecular dynamics simulation
Journal of Molecular Modeling (2017)
-
PEGylated liposomes prepared with polyborane instead of cholesterol for BNCT: characteristics and biodistribution evaluation
Colloid and Polymer Science (2016)
-
On-Command Drug Release from Nanochains Inhibits Growth of Breast Tumors
Pharmaceutical Research (2014)
