Abstract
NORMAL plasma fibrinogen concentrations are critical to haemo-stasis. Higher fibrinogen concentrations are associated with increasing risk of atherosclerotic disease1 and with graft stenosis and occlusion after saphenous vein bypass surgery2,3. Vein graft stenosis is characterized by the localized proliferation of intimal smooth muscle cells, causing narrowing of the graft with increased risk of thrombotic occlusion. In rabbit arteries, fibrino-peptide B is reported to have both vasoconstrictor and mitogenic properties4,5. We report here that fibrinopeptides had no vaso-active effects on saphenous vein rings; however, fibrinogen (0–2 μM) affected an endothelium-dependent relaxation, followed by recontraction at higher concentrations. The fibrinogen-mediated relaxation was inhibited by K+-channel blockers and antibodies to ICAM-1. Coupled signalling pathways for the synthesis of vasoactive mediators and mitogens could underlie the association between fibrinogen and the development of vein graft pathology.
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Hicks, R., Golledge, J., Mir-Hasseine, R. et al. Vasoactive effects of fibrinogen on saphenous vein. Nature 379, 818–820 (1996). https://doi.org/10.1038/379818a0
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DOI: https://doi.org/10.1038/379818a0
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