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Diet and snake venom evolution

Nature volume 379, pages 537–540 (1996)Cite this article

Abstract

VENOM composition within snake species can show considerable geographical variation1, an important consideration because bites by conspecific populations may differ in symptomatology and require different treatments2–5. The underlying causes of this phenomenon have never been explained. Here we present evidence that the variation in the venom of the pitviper Calloselasma rhodostoma (Serpentes: Viperidae) is closely associated with its diet. We also evaluated other possible causes of geographic variation in venom using partial Mantel tests6–10 and independent contrasts11, but rejected both contemporary gene flow (estimated from geographical proximity) and the phylogenetic relationships (assessed by analysis of mitochondrial DNA) among populations as important influences upon venom evolution. As the primary function of viperid venom is to immobilize and digest prey12–14 and prey animals vary in their susceptibility to venom15,16, we suggest that geographical variation in venom composition reflects natural selection for feeding on local prey.

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References

  1. Chippaux, J.-P., Williams, V. & White, J. Toxicon 29, 1279–1303 (1991).

    Article  CAS  Google Scholar 

  2. Barrio, A. & Brazil, O. V. Acta physiol. Lat. Am. 1, 291–308 (1951).

    CAS  PubMed  Google Scholar 

  3. Warrell, D. A. in Natural Toxins: Animal, Plant and Microbial. (ed. Harris, J. B.) 25–45 (Clarendon, Oxford, 1986).

    Google Scholar 

  4. Jayanthi, G. P. & Veerabasappa Gowda, T. Toxicon 26, 257–264 (1988).

    Article  CAS  Google Scholar 

  5. Wüster, W., Otsuka, S., Malhotra, A. & Thorpe, R. S. Biol. J. Linn. Soc. 47, 97–113 (1992).

    Article  Google Scholar 

  6. Brown, R. P., Thorpe, R. S. & Baez, M. Nature 352, 60–62 (1991).

    Article  ADS  Google Scholar 

  7. Thorpe, R. S. & Baez, M. Biol. J. Linn. Soc. 48, 75–87 (1993).

    Article  Google Scholar 

  8. Thorpe, R. S., et al. in Phylogenetics and Ecology (eds. Eggleton, P. & Vane-Wright, R.) 189–206 (Linnean Soc. Symp. Ser. No. 17, Academic, London 1994).

    Google Scholar 

  9. Castellano, S., Malhotra, A. & Thorpe, R. S. Biol. J. Linn. Soc. 52, 365–375 (1994).

    Article  Google Scholar 

  10. Thorpe, R. S. Malhotra, A., Black, H., Daltry, J. C. & Wüster, W. Phil. Trans. R. Soc. Lond. B349, 61–68 (1995).

    Article  Google Scholar 

  11. Felsenstein, J. Am. Nat. 125, 1–15 (1985).

    Article  Google Scholar 

  12. Thomas, R. G. & Pough, F. H. Toxicon 17, 221–228 (1979).

    Article  CAS  Google Scholar 

  13. Mackessy, S. P. Copeia 1988, 92–101 (1988).

    Article  Google Scholar 

  14. Hayes, W. K. Toxicon 29, 867–875 (1991).

    Article  CAS  Google Scholar 

  15. Minton, S. A. & Minton, S. R. Venomous Reptiles (Scribners, New York, 1969).

    Google Scholar 

  16. Elliott, W. B. in Biology of the Reptilia, Physiology B vol. 8 (eds Gans, C. & Gans, K. A.) 163–435 (Academic, London, 1978).

    Google Scholar 

  17. Tan, N.-H. Tropical Biomedicine 8, 91–103 (1991).

    Google Scholar 

  18. Tu, A. T. & Adams, B. L. Nature 217, 761–762 (1968).

    Article  ADS  Google Scholar 

  19. Foote, R. & MacMahon, J. A. Comp. Biochem. Physiol. 57B, 235–241 (1977).

    Google Scholar 

  20. Chen, Y., Wu, X. & Zhao, E. Toxicon 22, 53–61 (1984).

    Article  CAS  Google Scholar 

  21. Pough, F. H. & Groves, J. D. Am. Zool. 23, 443–454 (1983).

    Article  Google Scholar 

  22. Boche, J., Chippaux, J. P. & Courtois, B. Bull. Soc. Path. Exot. 74, 356–366 (1981).

    CAS  PubMed  Google Scholar 

  23. Gregory-Dwyer, V. M., Egan, N. B., Bianchi Bosisio, A., Righetti, P. G. & Russell, F. E. Toxicon 24, 995–1000 (1986).

    Article  CAS  Google Scholar 

  24. Tu, A. T. & Ganthavorn, S. J. Herpet. 12, 105–107 (1978).

    Article  Google Scholar 

  25. Kocher, T. D. et al. Proc. natn. Acad. Sci. U.S.A. 86, 6196–6200 (1989).

    Article  ADS  CAS  Google Scholar 

  26. Moritz, C., Schneider, C. J. & Wake, D. B. Syst. Biol. 41, 273–291 (1992).

    Article  Google Scholar 

  27. Felsenstein, J. PHYLIP version 3.3 (Univ. Washington, Seattle, 1990).

    Google Scholar 

  28. McElroy, D., Moran, P., Bermingham, E. & Kornfield, I. Restriction Enzyme Analysis Package version 4.0 (Univ. Maine, Massachusetts, 1992).

    Google Scholar 

  29. Rice, W. R. Evolution 43, 223–225 (1989).

    Article  Google Scholar 

Download references

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Author notes

  1. Wolfgang Wüster: To whom correspondence should be addressed.

Authors and Affiliations

  1. School of Biological Sciences, University of Wales, Brambell Building, Bangor, Gwynedd, LL57 2UW, UK

    Jennifer C. Daltry, Wolfgang Wüster & Roger S. Thorpe

Authors
  1. Jennifer C. Daltry
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  2. Wolfgang Wüster
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  3. Roger S. Thorpe
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Daltry, J., Wüster, W. & Thorpe, R. Diet and snake venom evolution. Nature 379, 537–540 (1996). https://doi.org/10.1038/379537a0

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