Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Anandamide may mediate sleep induction

This is a preview of subscription content

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Dose-dependent inhibition of [14C]anandamide hydrolysis by N18TG2 cell 10,000g particulate fractions.


  1. 1

    Cravatt, B. F. et al. Science 268, 1506–1509(1995).

    Google Scholar 

  2. 2

    Devane, W. A. et al. Science 258, 1946–1949(1992).

    Google Scholar 

  3. 3

    Fride, E. & Mechoulam, R. Eur. J. Pharmacol. 231, 313–314(1993).

    Google Scholar 

  4. 4

    Piomelli, D. Arachidonic Acid in Cell Signaling 167–195 (Landes Co., Austin, 1996).

    Book  Google Scholar 

  5. 5

    Santucci, V., Storme, J. J., Soubrie, P. & Le Fur, G. Life Sci. 58, 103–110(1996).

    Google Scholar 

  6. 6

    Martin, B. R. et al. Pharmacol. Biochem. Behav. 40, 471–478(1991).

    Google Scholar 

  7. 7

    Boring, D. L., Berglund, B. A. & Howlett, A. C. Prostaglandins Leukot. Essent. Fatty Acids 55, 207–210(1996).

    Google Scholar 

  8. 8

    Maurelli, S. et al. FEBS Lett. 277, 82(1995).

    Google Scholar 

  9. 9

    Cravatt, B. F. et al. Nature 384, 83–87(1996).

    Google Scholar 

  10. 10

    Di Marzo, V. et al. Nature 372, 686–691(1994).

    Google Scholar 

  11. 11

    Vogel, Z. et al. J. Neurochem. 61, 352–355(1993).

    Google Scholar 

  12. 12

    di Tomaso, E., Beltramo, M. & Piomelli, D. Nature 382, 677–678(1996).

    ADS  CAS  Article  Google Scholar 

Download references

Author information



Rights and permissions

Reprints and Permissions

About this article

Cite this article

Mechoulam, R., Fride, E., Hanu, L. et al. Anandamide may mediate sleep induction. Nature 389, 25–26 (1997).

Download citation

Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing