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Nucleation of microtubule assembly by a γ-tubulin-containing ring complex

Abstract

The highly conserved protein γ-tubulin is required for microtubule nucleation in vivo. When viewed in the electron microscope, a highly purified γtubulin complex from Xenopus consisting of at least seven different proteins is seen to have an open ring structure. This complex acts as an active microtubulenucleating unit which can cap the minus ends of microtubules in vitro.

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Zheng, Y., Wong, M., Alberts, B. et al. Nucleation of microtubule assembly by a γ-tubulin-containing ring complex. Nature 378, 578–583 (1995). https://doi.org/10.1038/378578a0

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