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Requirement for neuregulin receptor erbB2 in neural and cardiac development

Nature volume 378, pages 394398 (23 November 1995) | Download Citation

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Abstract

THE receptor erbB2/neu is a member of the epidermal growth factor receptor (EGFR or erbB) family that also includes erbB3 and erbB41. Amplification of the erbB2/neu gene is found in many cancer types and its overexpression is correlated with a poor prognosis for breast and ovarian cancer patients2. Investigation of the biology of erbB2 led to the identification of a family of ligands termed neuregulins which included the neu-differentiation factors3,4, the heregulins5, a ligand with acetylcholine-receptor-inducing activity6 and glial growth factor7. Several lines of evidence suggest that heterodimerization of erbB2 with other erbB receptors is required for neuregulin signalling1. Here we investigate the developmental role of erbB2 in mammalian development in mice carrying an erbB2 null allele. We find that mutant embryos die before Ell, probably as a result of dysfunctions associated with a lack of cardiac trabeculae. Development of cranial neural-crest-derived sensory ganglia was markedly affected. Dil retrograde tracing revealed that the development of motor nerves was also compromised. Our results demonstrate the importance of erbB2 in neural and cardiac development.

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Author information

Author notes

    • Hua Chen
    •  & Mien-Chie Hung

    Department of Tumor Biology, M. D. Anderson Cancer Center,University of Texas, Houston, Texas 77030, USA

    • Brian Bates

    Whitehead Institute, 9 Cambridge Center, Cambridge,Massachusetts 02142, USA

Affiliations

  1. The Clayton Foundation Laboratories for Peptide Biology,The Salk Institute, 10010 North Torrey Pines Road, La Jolla,California 92037, USA

    • Kuo-Fen Lee
    • , Horst Simon
    • , Hua Chen
    • , Brian Bates
    • , Mien-Chie Hung
    •  & Christopher Hauser

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https://doi.org/10.1038/378394a0

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