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A homeobox gene essential for zebrafish notochord development

Abstract

The notochord is a midline mesodermal structure with an essential patterning function in all vertebrate embryos. Zebrafish floating head (flh) mutants lack a notochord, but develop with prechordal plate and other mesodermal derivatives, indicating that flh functions specifically in notochord development. We show that floating head is the zebrafish homologue of Xnot, a homeobox gene expressed in the amphibian organizer and notochord. We propose that flh regulates notochord precursor cell fate.

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Talbot, W., Trevarrow, B., Halpern, M. et al. A homeobox gene essential for zebrafish notochord development. Nature 378, 150–157 (1995). https://doi.org/10.1038/378150a0

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