Abstract
The activity of a variety of genes whose products are involved in DNA replication and cell-cycle progression are regulated by E2F transcription factors, which bind to E2F sites on DNA in cooperation with members of the DP family of transcription factors1. E2F sites can act as both positive and negative control elements2. Transcriptional activation from E2F sites is mediated by ‘free’ E2F, whereas repression conventionally requires the formation of a complex with a pocket protein (retinoblastoma protein (RB), p107 or p130)3. Here we describe an E2F-like protein, termed EMA (for E2F-binding site modulating activity), which can act as a repressor of transcription without a pocket protein.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
E2F6 initiates stable epigenetic silencing of germline genes during embryonic development
Nature Communications Open Access 11 June 2021
-
HOXC9 directly regulates distinct sets of genes to coordinate diverse cellular processes during neuronal differentiation
BMC Genomics Open Access 25 November 2013
-
Overexpression of E2F-5 correlates with a pathological basal phenotype and a worse clinical outcome
British Journal of Cancer Open Access 03 March 2009
Access options
Subscribe to Journal
Get full journal access for 1 year
$199.00
only $3.90 per issue
All prices are NET prices.
VAT will be added later in the checkout.
Tax calculation will be finalised during checkout.
Buy article
Get time limited or full article access on ReadCube.
$32.00
All prices are NET prices.
References
Beijersbergen, R. L. & Bernards, R. Biochim. Biophys. Acta 1287, 103–120 (1996).
Weintraub, S. J. et al. Nature 358, 259–261 (1992).
Weinberg, R. A. Cell 81, 323–330 (1995).
Chittenden, T. et al. Cell 65, 1073–1082 (1991).
Kovesdi, I., Reichel, R. & Nevins, J. R. Cell 45, 219–228 (1986).
Hanna Rose, W. & Hansen, U. Trends Genet. 12, 229–234 (1996).
Yew, P. R. et al. Genes Dev. 8, 190–202 (1994).
Weintraub, S. J. et al. Nature 375, 812–815 (1995).
Hagemeier, C. et al. Nucleic Acids Res. 21, 4998–5004 (1993).
Vojtek, A. B. et al. Cell 74, 205–214 (1993).
Hagemeier, C. et al. EMBO J. 13, 2897–2903 (1994).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Morkel, M., Wenkel, J., Bannister, A. et al. An E2F-like repressor of transcription. Nature 390, 567–568 (1997). https://doi.org/10.1038/37507
Published:
Issue Date:
DOI: https://doi.org/10.1038/37507
This article is cited by
-
E2F6 initiates stable epigenetic silencing of germline genes during embryonic development
Nature Communications (2021)
-
HOXC9 directly regulates distinct sets of genes to coordinate diverse cellular processes during neuronal differentiation
BMC Genomics (2013)
-
Overexpression of E2F-5 correlates with a pathological basal phenotype and a worse clinical outcome
British Journal of Cancer (2009)
-
RB and cell cycle progression
Oncogene (2006)
-
The E2F transcriptional network: old acquaintances with new faces
Oncogene (2005)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
