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Requirement for LIml in head-organizer function

Abstract

Liml is a homeobox gene expressed in the organizer region of mouse embryos. To investigate the role of Liml during embryogenesis, a targeted deletion of the Liml gene was generated in embryonic stem cells. Embryos homozygous for the null allele lacked anterior head structures but the remaining body axis developed normally. A partial secondary axis developed anteriorly in some mutant embryos. Liml is thus an essential regulator of the vertebrate head organizer.

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Shawlot, W., Behringer, R. Requirement for LIml in head-organizer function. Nature 374, 425–430 (1995). https://doi.org/10.1038/374425a0

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