Digital imaging spectrophotometers can simultaneously measure the spectra of hundreds of features in a two-dimensional scene. While a variety of applications can be anticipated, a colorimetric analysis of mutants expressing pigmented proteins has already led to the development of efficient algorithms for optimizing combinatorial mutagenesis.
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References
Yang, M. M. & Youvan, D. C. Bio/Technology 6, 939–942 (1988).
Arkin, A. et al. Bio/Technology 8, 746–749 (1990).
Youvan, D. C., Goldman, E. R., Delagrave, S. & Yang, M. M. Meth. Enzym. (in the press).
Yang, M. M. Am. Biotech. Lab. (in the press).
Goldman, E. R. & Youvan, D. C. Bio/Technology 10, 1557–1561 (1992).
Delagrave, S., Goldman, E. R. & Youvan, D. C. Protein Engng 6, 327–331 (1993).
Delagrave, S. & Youvan, D. C. Bio/Technology 11, 1548–1552 (1993).
Arkin, A. P. & Youvan, D. C. Bio/Technology 10, 297–300 (1992).
Barbas, C. F., Bain, J. D., Hoekstra, D. M. & Lerner, R. A. Proc. natn. Acad. Sci. U.S.A. 89, 4457–4461 (1992).
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Youvan, D. Imaging sequence space. Nature 369, 79–80 (1994). https://doi.org/10.1038/369079a0
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DOI: https://doi.org/10.1038/369079a0
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