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Cell-cycle calcium transients driven by cyclic changes in inositol trisphosphate levels

Nature volume 368, pages 875–878 (1994)Cite this article

Abstract

TRANSIENT changes in intracellular calcium ([Ca2+]i) have been shown to punctuate the cell cycle in various types of cells in culture1–5 and in early embryos6–12. The [Ca2+]i transients are correlated with cell-cycle events: pronuclear migration, nuclear envelope breakdown, the metaphase–anaphase transition of mitosis, and cytokinesis. Mitotic events can be induced by injecting calcium and prevented by injecting calcium chelators into the sea urchin embryo10,13. Cell-cycle calcium transients differ from the transients linked to membrane signal transduction pathways: they are generated by an endogenous mechanism, not by plasma membrane receptor complexes, and their trigger is unknown. We report here that the phosphoinositide messenger system oscillates during the early embryonic cell cycle in the sea urchin, leading to cyclic increases in inositol trisphosphate that trigger cell-cycle [Ca2+]i transients and mitosis by calcium release from intracellular stores.

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Author notes

  1. Brigitte Ciapa

    Present address: Groupe de Recherche sur I'interaction Gamétique, Faculté de Médicine, Av. de Vallambrose, 06107, Nice, Cedex 02, France

Authors and Affiliations

  1. Laboratoire de Physiologie Cellulaire et Comparée, Faculté des Sciences, Pare Valrose, BP 71, 06108, Nice, Cedex 02, France

    Brigitte Ciapa

  2. Unité INSERM 303, BP 3, 06230, Villefranche-Sur-Mer, France

    Danielle Pesando

  3. Department of Physiology, University College London, Gower Street, London, WC1E 6BT, UK

    Martin Wilding & Michael Whitaker

Authors
  1. Brigitte Ciapa
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  2. Danielle Pesando
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  3. Martin Wilding
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  4. Michael Whitaker
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Ciapa, B., Pesando, D., Wilding, M. et al. Cell-cycle calcium transients driven by cyclic changes in inositol trisphosphate levels. Nature 368, 875–878 (1994). https://doi.org/10.1038/368875a0

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