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Oligonucleotide probe design — a new approach

Nature volume 367, pages 759–761 (1994)Cite this article

The use of oligonucleotides for gene ampliation, as diagnostic probes or antisense-based drugs can be optimized by minimizing the possibility of nonspecific hybridization.

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References

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Author notes

  1. Masato Mitsuhashi, Allan Cooper, Mieko Ogura, Tatsuo Shinagawa, Katsusuke Yano and Toshiaki Hosokawa: We thank Dennis Coad, David Hyndman, Dr Takashi Ishikawa and Dr Yasushi Ichikawa for their helpful comments. For more information, fill in reader service number 100.

Authors and Affiliations

  1. Advanced Gene Computing Technologies (AGCT), Inc., 2102 Business Center Drive, Suite 170, Irvine, California, 92715, USA

    Masato Mitsuhashi

  2. Hitachi Chemical Research Center, Inc., Irvine, CA 92715, USA

    Masato Mitsuhashi

  3. AGCT, Inc. and DigitalWord, Bellevue, Washington, 98008, USA

    Allan Cooper

  4. Hitachi Chemical Research Center, Inc.,

    Mieko Ogura

  5. the Third Department of Internal Medicine, Nagasaki University, School of Medicine, Nagasaki, Japan

    Tatsuo Shinagawa & Katsusuke Yano

  6. Hitachi Chemical Company Ltd, Tokyo, Japan

    Toshiaki Hosokawa

Authors
  1. Masato Mitsuhashi
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  2. Allan Cooper
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  3. Mieko Ogura
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  4. Tatsuo Shinagawa
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  5. Katsusuke Yano
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  6. Toshiaki Hosokawa
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Mitsuhashi, M., Cooper, A., Ogura, M. et al. Oligonucleotide probe design — a new approach. Nature 367, 759–761 (1994). https://doi.org/10.1038/367759a0

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