The use of oligonucleotides for gene ampliation, as diagnostic probes or antisense-based drugs can be optimized by minimizing the possibility of nonspecific hybridization.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Ex Vivo Induction of mRNA in Human Whole Blood as a New Platform of Drug and Dietary Supplement Development
Pharmaceutical Research Open Access 09 January 2008
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Bernstam, V. A. in Handbook of Gene Level Diagnostics in Clinical Practice 161–630 (CRC Press, Florida, 1992).
Mitsuhashi, M. et al. Nature 357, 519–520 (1992).
Saiki, R. K. et al. Science 230, 1350–1354 (1985).
Wu, D. Y. & Wallace, R. B. Gene 76, 245–254 (1989).
Reynolds, T. J. natn. Cancer Inst. 84, 288–290 (1992).
Mitsuhashi, M. & Hosokawa, T. Nippon Rinsho 52, 530–541 (1994).
March, C. J. et al. Nature 315, 641–647 (1985).
Iizuka, N., Kuge, S. & Nomoto, A. Virology 156, 64–73 (1987).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Mitsuhashi, M., Cooper, A., Ogura, M. et al. Oligonucleotide probe design — a new approach. Nature 367, 759–761 (1994). https://doi.org/10.1038/367759a0
Issue Date:
DOI: https://doi.org/10.1038/367759a0
This article is cited by
-
Ex Vivo Induction of mRNA in Human Whole Blood as a New Platform of Drug and Dietary Supplement Development
Pharmaceutical Research (2008)
-
Strategy for designing specific antisense oligonucleotide sequences
Journal of Gastroenterology (1997)