Abstract
THE Wnt genes encode conserved secreted proteins that play a role in normal development and tumorigenesis1,2. Little is known about the signal transduction pathways of Wnt gene products. One of the best characterized Wnt family members is the Drosophila segment polarity gene wingless3–6. We have investigated whether segment polarity genes with a wingless-like phenotype mediate the wingless signal. We used a wingless transgene controlled by a heat-shock promoter for genetic epistasis experiments. We show that wingless acts through dishevelled and armadillo to affect the expression of the homeobox gene engrailed and cuticle differentiation.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Nusse, R. & Varmus, H. E. Cell 69, 1073–1087 (1992).
McMahon, A. P. Trends Genet. 8, 236–242 (1992).
Baker, N. E. EMBO J. 6, 1765–1773 (1987).
Rijsewijk, F. et al. Cell 50, 649–657 (1987).
Cabrera, C. V., Alonso, M. C., Johnston, P., Phillips, R. G. & Lawrence, P. A. Cell 50, 659–663 (1987).
Nüsslein-Volhard, C. & Wieschaus, E. Nature 287, 795–801 (1980).
Van den Heuvel, M., Nusse, R., Johnston, P. & Lawrence, P. A. Cell 59, 739–749 (1989).
González, F., Swales, L., Bejsovec, A., Skaer, H. & Martinez-Arias, A. Mech. Dev. 35, 43–54 (1991).
DiNardo, S., Sher, E., Heemskerk-Jorgens, J., Kassis, J. & O'Farrell, P. Nature 332, 604–609 (1988).
Martinez-Arias, A., Baker, N. E. & Ingham, P. W. Development 103, 157–70 (1988).
Heemskerk, J., DiNardo, S., Kostriken, R. & O'Farrell, P. H. Nature 352, 404–410 (1991).
Bejsovec, A. & Martinez-Arias, A. Development 113, 471–185 (1991).
Dougan, S. & Dinardo, S. Nature 360, 347–350 (1992).
Klingensmith, J., Noll, E. & Perrimon, N. Devl Biol 134, 130–145 (1989).
Perrimon, N. & Mahowald, A. P. Devl Biol 119, 587–600 (1987).
Wieschaus, E. & Riggleman, R. Cell 49, 177–84 (1987).
Noordermeer, J., Johnston, P., Rijsewijk, F., Nusse, R. & Lawrence, P. Development 116, 711–719 (1992).
Wieschaus E. & Nusslein-Volhard, C. in Drosophila: A Practical Approach (ed. Roberts, D. B.) (IRL, Oxford, 1986).
Mohler, J. Genetics 120, 1061–1072 (1988).
Sampedro, J., Johnston, P. & Lawrence, P. A. Development 117, 677–687 (1993).
Klingensmith, J., Nusse, R. & Perrimon, N. Genes Dev. (in the press).
Riggleman, B., Schedl, P. & Wieschaus, E. Cell 63, 549–560 (1990).
Peifer, M. & Wieschaus, E. Cell 63, 1167–1178 (1990).
Van den Heuvel, M., Harryman-Samos, C., Klingensmith, J., Perrimon, N. & Nusse, R. EMBO J. (in the press).
Lee, J. J., von Kessler, D. P., Parks, S. & Beachy, P. A. Cell 71, 33–50 (1992).
Ingham, P. W., Taylor, A. M. & Nakano, Y. Nature 353, 184–187 (1991).
Bourouis, M. et al. EMBO J. 9, 2877–2884 (1990).
Siegfried, E., Perkins, L. A., Capaci, T. M. & Perrimon, N. Nature 345, 825–829 (1990).
Siegfried, E., Chou, T. B. & Perrimon, N. Cell 71, 1167–1179 (1992).
Siegfried, E., Wilder, E. L. & Perrimon, N. Nature 367, 76–80 (1994).
Chou, T. B. & Perrimon, N. Genetics 131, 643–653 (1992).
Eberl, D. F., Perkins, L. A., Engelstein, M., Hilliker, A. J. & Perrimon, N. Genetics 130, 569–583 (1992).
Kania, M. A., Bonner, A. S., Duffy, J. B. & Gergen, J. P. Genes Dev. 4, 1701–1713 (1990).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Noordermeer, J., Klingensmith, J., Perrimon, N. et al. dishevelled and armadillo act in the Wingless signalling pathway in Drosophila. Nature 367, 80–83 (1994). https://doi.org/10.1038/367080a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/367080a0
This article is cited by
-
Disruption of Tip60 HAT mediated neural histone acetylation homeostasis is an early common event in neurodegenerative diseases
Scientific Reports (2020)
-
Dishevelled has a YAP nuclear export function in a tumor suppressor context-dependent manner
Nature Communications (2018)
-
USP20 positively regulates tumorigenesis and chemoresistance through β-catenin stabilization
Cell Death & Differentiation (2018)
-
Prostate cancer bone metastases acquire resistance to androgen deprivation via WNT5A-mediated BMP-6 induction
British Journal of Cancer (2014)
-
Analysis of flooding-responsive proteins localized in the nucleus of soybean root tips
Molecular Biology Reports (2014)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.